References

Published scientific journals that have proven the effectiveness of the TBIFinder technique
  • Ruiter, K. I., Boshra, R., Doughty, M., Noseworthy, M., & Connolly, J. F. (2019). Disruption of function: Neurophysiological markers of cognitive deficits in retired football players. Clinical neurophysiology, 130(1), 111-121.

  • Ho, R. A., Hall, G. B., Noseworthy, M. D., & DeMatteo, C. (2018). An Emotional Go/No-Go fMRI study in adolescents with depressive symptoms following concussion. International journal of psychophysiology, 132, 62-73.

  • Dona O, Noseworthy MD, DeMatteo C, Connolly JF. (2017) Regional fractal analysis of brain blood oxygenation level dependent (BOLD) signals from children with mild traumatic brain injury (mTBI). PLoS One Jan 10; 12(1): e0169647. doi:10.1371/journal. pone.0169647

  • Noseworthy MD, Stillo D, Ho R, Connolly JF DeMatteo C. (2017) Patient-specific assessment of mild traumatic brain injury (mTBI) in children using Z-Scored diffusion tensor imaging (DTI). European Society for Magnetic Resonance in Medicine and Biology (ESMRMB). 30:199. Barcelona, Spain.

  • Ho, R., DeMatteo, C., Hall, G., & Noseworthy, M. (2017, January). Exploring the biological and clinical effect of depressive symptoms in youth following concussion. In BRAIN INJURY (Vol. 31, No. 6-7, pp. 953-953). 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA: TAYLOR & FRANCIS INC.

  • Dona, O., Noseworthy, M. D., DeMatteo, C., & Connolly, J. F. (2017). Fractal Analysis of Brain Blood Oxygenation Level Dependent (BOLD) signals from children with mild traumatic brain injury (mTBI). PloS one, 12(1), e0169647.

  • Dona, O., Hall, G. B., & Noseworthy, M. D. (2017). Temporal fractal analysis of the rs-BOLD signal identifies brain abnormalities in autism spectrum disorder. PloS one, 12(12), e0190081.

  • Lemus, O. M. D., & Noseworthy, M. (2016). Poster‐06: Fractal Analysis of the brain blood oxygenation level dependent (BOLD) signal of mild traumatic brain injury (mTBI) patients. Medical Physics, 43(8Part1), 4936-4936.

  • Warsi, M. A., Weber, A. M., & Noseworthy, M. D. (2013). Brain Fractal Blood-Oxygen Level Dependent (BOLD) Signals: The Effect of MRI Acquisition Parameters on Temporal Fractal Dimension (FD) Stability. Visualization, Image Processing and Computation in Biomedicine, 2(1).

  • Warsi, M. A., Hasey, G. M., Molloy, W., & Noseworthy, M. D. (2012, April). Fractal Dimension Compared to Resting State Network Analysis of BOLD MRI in Alzheimer's Disease. In Biological Psychiatry (Vol. 71, No. 8, pp. 170S-170S). 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA: ELSEVIER SCIENCE INC.

  • Warsi, M. A., Molloy, W., & Noseworthy, M. D. (2012). Correlating brain blood oxygenation level dependent (BOLD) fractal dimension mapping with magnetic resonance spectroscopy (MRS) in Alzheimer’s disease. Magnetic Resonance Materials in Physics, Biology and Medicine, 25(5), 335-344.

  • Warsi, M., Molloy, D. W., Standish, T., Wardlaw, G., & Noseworthy, M. D. (2010). BOLD Signal Fractal Dimension Mapping in AD Demonstrates Increase Microvascular Activity and Metabolism When Combined With Spectroscopy. In Proc. Intl. Soc. Mag. Reson. Med (Vol. 18, p. 4242).

  • Wardlaw, G., Wong, R., & Noseworthy, M. D. (2008). Identification of intratumour low frequency microvascular components via BOLD signal fractal dimension mapping. Physica Medica, 24(2), 87-91.

  • Jones, G. E., Wong, R., Shipwright, S., Dryden, T., Sagar, S. M., Wardlaw, G. M., ... & Noseworthy, M. D. (2011). Alterations in Resting-State BOLD MRI Fractal Dimension After Swedish Massage. Critical Reviews™ in Physical and Rehabilitation Medicine, 23(1-4).

Published scientific journals that have proven the effectiveness of the scientific concepts employed in the TBIFinder technique

Mild Traumatic Brain Injury (mTBI) or Concussion


  • Elbin RJ, Knox J, Kegel N, Schatz P, Lowder HB, French J, Burkhart S, Collins MW, Kontos AP. (2016) Assessing symptoms in adolescents following sport-related concussion: A comparison of four different approaches. Appl Neuropsychol Child. 5(4):294-302.
  • Wintermark M, Coombs L, Druzgal TJ, Field AS, Filippi CG, Hicks R, Horton R, Lui YW, Law M, Mukherjee P, Norbash A, Riedy G, Sanelli PC, Stone JR, Sze G, Tilkin M, Whitlow CT, Wilde EA, York G, Provenzale JM. (2015). Traumatic brain injury imaging research roadmap. American College of Radiology Head Injury Institute. AJNR Am J Neuroradiol. 36(3):E12-23.
  • Zhu, D. C., Covassin, T., Nogle, S., Doyle, S., Russell, D., Pearson, R. L., Monroe, J., Liszewski, C. M., DeMarco, J. K., and Kaufman, D. I. (2015). A potential biomarker in sports-related concussion: brain functional connectivity alteration of the default-mode network measured with longitudinal resting-state fmri over thirty days. Journal of neurotrauma, 32(5), 327–341.
  • Zetterberg H, Smith DH, Blennow K. (2013). Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nature Rev Neurol 9(4):201-210.
  • Lannsjo M, Backheden M, Johansson U, Af Geijerstam JL, Borg J. (2013) Does head CT scan pathology predict outcome after mild traumatic brain injury? Eur J Neurol 20:124-129.
  • Galetta MS, Galetta KM, McCrossin J, Wilson JA, Moster S, Galetta SL, Balcer LJ, Dorshimer GW, Master CL. (2013) Saccades and memory: baseline associations of the King-Devick and SCAT2 SAC tests in professional ice hockey players. J Neurol Sci. 328(1-2):28-31.
  • McCrory, P., Meeuwisse, W. H., Aubry, M., Cantu, B., Dvorák, J., Echemendia, R. J., & Turner, M. (2013). Consensus statement on concussion in sport. Br J Sports Med, 47(5), 250-258.
  • Jeter CB, Hergenroeder GW, Hylin MJ, Redell JB, Moore AN, Dash PK. (2013). Biomarkers for the diagnosis and prognosis of mild traumatic brain injury/concussion. J. Neurotrauma 30(8):657-670.
  • Tremblay, S., De Beaumont, L., Henry, L. C., Boulanger, Y., Evans, A. C., Bourgouin, P., Poirier, J., Th ́eoret, H., and Lassonde, M. (2012). Sports concussions and aging: a neuroimaging investigation. Cerebral cortex, 23(5), 1159–1166. 
  • Johnson, B., Zhang, K., Gay, M., Horovitz, S., Hallett, M., Sebastianelli, W., and Slobounov, S. (2012). Alteration of brain default network in subacute phase of injury in concussed individuals: resting-state fmri study. Neuroimage, 59(1), 511– 518.
  • Galetta KM, Brandes LE, Maki K, Dziemianowicz MS, Laudano E, Allen M, Lawler K, Sennett B, Wiebe D, Devick S, Messner LV, Galetta SL, Balcer LJ. (2011) The King-Devick test and sports-related concussion: study of a rapid visual screening tool in a collegiate cohort. J Neurol Sci. 2011 309(1-2):34- 39.
  • Stern, R. A., Riley, D. O., Daneshvar, D. H., Nowinski, C. J., Cantu, R. C., and McKee, A. C. (2011). Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy. Pm&r, 3(10), S460–S467. 
  • Kim JJ, Gean AD. (2011) Imaging for the Diagnosis and Management of Traumatic Brain Injury. Neurotherapeutics: J. Amer Soc. Exp. Neuro Therap. 8:39-53.
  • Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, Robson R, Thabane M, Giangregorio L, Goldsmith CH. (2010). A tutorial on pilot studies: the what, why and how. BMC medical research methodology. http://www.biomedcentral.com/1471-2288/10.
  • Biasca, N. and Maxwell, W. L. (2007). Minor traumatic brain injury in sports: a review in order to prevent neurological sequelae. Progress in brain research, 161, 263–291.
  • Belanger, H. G., Vanderploeg, R. D., Curtiss, G., and Warden, D. L. (2007). Recent neuroimaging techniques in mild traumatic brain injury. The Journal of neuropsy- chiatry and clinical neurosciences, 19(1), 5–20. 

 

  • Langlois JA, Rutland-Brown W, Wald MM. (2006). The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehab 21(5):375-378.
  • Bigler, E. D. (2004). Neuropsychological results and neuropathological findings at autopsy in a case of mild traumatic brain injury. Journal of the International Neuropsychological Society, 10(05), 794–806. 
  • Hughes DG, Jackson A, Mason DL, Berry E, Hollis S, Yates DW. (2004) Abnormalities on magnetic resonance imaging seen acutely following mild traumatic brain injury: correlation with neuropsychological tests and delayed recovery. Neuroradiology 46:550-558.
  • Kay A, Teasdale G. (2001). Head injury in the United Kingdom. World J Surg 25:1210-1220.
  • Gennarelli, T. A., Thibault, L. E., and Graham, D. I. (1998). Diffuse axonal injury: an important form of traumatic brain damage. The Neuroscientist, 4(3), 202–215.

Diffusion Tensor Imaging (DTI)

  • Asken BM, DeKosky ST, Clugston JR, Jaffee MS, Bauer RM. (2018) Diffusion Tensor Imaging findings in adult civilian, military and sports related mild traumatic brain injury (mTBI): a systematic review. Brain Img Behav 2018 Feb; 1-28 https://doi.org/10.1007/s11682-017-9708-9.
  • Strauss SB, Kim N, Branch CA, Kahn ME, Kim M, Lipton RB, Provataris JM, Scholl HF, Zimmerman ME, Lipton ML. (2016) Bidirectional changes in anisotropy are associated with outcomes in mild traumatic brain injury. AJNR Am J Neuroradiol. 2016 Jun 9.
  • Multani, N., Goswami, R., Khodadadi, M., Ebraheem, A., Davis, K. D., Tator, C. H., Wennberg, R., Mikulis, D. J., Ezerins, L., and Tartaglia, M. C. (2016). The associa- tion between white-matter tract abnormalities, and neuropsychiatric and cognitive symptoms in retired professional football players with multiple concussions. Journal of neurology, 263(7), 1332–1341. 
  • Goswami, R., Dufort, P., Tartaglia, M., Green, R., Crawley, A., Tator, C., Wennberg, R., Mikulis, D., Keightley, M., and Davis, K. D. (2016). Frontotemporal correlates of impulsivity and machine learning in retired professional athletes with a history of multiple concussions. Brain structure & function, 221, 1911. 
  • Sexton, C. E., Walhovd, K. B., Storsve, A. B., Tamnes, C. K., Westlye, L. T., Johansen-Berg, H., and Fjell, A. M. (2014). Accelerated changes in white matter microstructure during aging: a longitudinal diffusion tensor imaging study. Journal of Neuroscience, 34(46), 15425–15436. 
  • Winkler, A. M., Ridgway, G. R., Webster, M. A., Smith, S. M., and Nichols, T. E. (2014). Permutation inference for the general linear model. Neuroimage, 92, 381– 397. 
  • Sasaki, T., Pasternak, O., Mayinger, M., Muehlmann, M., Savadjiev, P., Bouix, S., Kubicki, M., Fredman, E., Dahlben, B., Helmer, K. G., et al. (2014). Hockey concussion education project, part 3. white matter microstructure in ice hockey players with a history of concussion: a diffusion tensor imaging study. Journal of neurosurgery, 120(4), 882–890. 
  • Bouix S, Pasternak O, Rathi Y, Pelavin PE, Zafonte R, Shenton ME. (2013) Increased gray matter diffusion anisotropy in patients with persistent post-concussive symptoms following mild traumatic brain injury. PLoS One. Jun 11;8(6):e66205. doi: 10.1371/journal.pone.0066205. PMID: 23776631.
  • Shenton ME, Hamoda HM, Schneiderman JS, Bouix S, Pasternak O, Rathi Y, Vu MA, Purohit MP, Helmer K, Koerte I, Lin AP, Westin CF, Kikinis R, Kubicki M, Stern RA, Zafonte R. (2012) A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging Behav. 6(2):137-192.
  • Kinnunen KM, Greenwood R, Powell JH, Leech R, Hawkins PC, Bonnelle V, Patel MC, Counsell SJ, Sharp DJ. (2011) White matter damage and cognitive impairment after traumatic brain injury. Brain 134(Pt 2):449-463.
  • Niogi SN, Mukherjee P, Ghajar J, Johnson C, Kolster RA, Sarkar R, Lee H, Meeker M, Zimmerman RD, Manley GT, McCandliss BD. (2008) Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury. AJNR 29:967-973.
  • Rutgers DR, Toulgoat F, Cazejust J, Fillard P, Lasjaunias P, Ducreux D. (2008) White matter abnormalities in mild traumatic brain injury: a diffusion tensor imaging study. AJNR 29:514-519.
  • Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., et al. (2006). Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage, 31(4), 1487–1505. 
  • Sullivan, E. V. and Pfefferbaum, A. (2006). Diffusion tensor imaging and aging. Neuroscience & Biobehavioral Reviews, 30(6), 749–761. 
  • Johansen-Berg, H., Behrens, T., Robson, M., Drobnjak, I., Rushworth, M., Brady, J., Smith, S., Higham, D., and Matthews, P. (2004). Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex. Proceedings of the National Academy of Sciences of the United States of America, 101(36), 13335–13340. 
  • Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S. (2004) Fiber tract-based atlas of human white matter anatomy. Radiology 230:77-87.
  • Smith DH, Meaney DF, Shull WH. (2003). Diffuse axonal injury in head trauma. J Head Trauma Rehabil 18:307-316.
  • Hofman, P. A., Stapert, S. Z., van Kroonenburgh, M. J., Jolles, J., de Kruijk, J., & Wilmink, J. T. (2001). MR imaging, single-photon emission CT, and neurocognitive performance after mild traumatic brain injury. American Journal of Neuroradiology, 22(3), 441-449.